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Other, greater people have done great things in quarantine way before you were born. I already knew that the late Sir Isaac Newton discovered things like optics, gravity, and the rules for Calculus, which he called the study of “fluxions”. But what I didn’t know is that in the two years he did so, he was in his early 20’s, and England suffered an epidemic of The Bubonic Plague, known as The Great Plague, in the years 1665-1666, long before infectious disease were known and understood. It is even worthy of remarking that so little was known of medicine generally that even Sir Isaac believed in alchemy until the day he died.

Prior to his quarantine he was thought of as an unremarkable undergraduate student, according to Wikipedia. But given two years cooped up where he lived and avoiding the Plague gave him time alone to come up with his brilliant theories on classical mechanics, using calculus to explain it mathematically.